Our research team participates in national and local studies, aimed at increasing our understanding of mental health conditions, improving the services we provide and helping to develop new treatments.
All research follows strict guidelines and governance procedures laid down by the National Institute for Health Research (NIHR).
If you are interested in participating in one of our research studies, please email firstname.lastname@example.org.
Current research projects we are recruiting for
April 2015: Valuing Active Life in Dementia (VALID)
This is a five year study funded by the National Institute for Health Research.
VALID is based upon work conducted in the Netherlands by Dr Maud Graff. They developed a ‘Community Occupational Therapy in Dementia’ (COTiD) intervention for people with mild to moderate dementia and their family carers/ supporters. The intervention is provided through a ten week programme in the homes and local communities of participants.
What does COTiD involve?
Dementia is a difficult illness to live with; both for the person with the diagnosis and for those who support them. However research has shown that people can be helped to undertake new learning, retain skills for longer and live a quality life with dementia, particularly through continued participation. COTiD has been designed to support those living in the early stages of dementia to maintain engagement with life. COTiD involves occupational therapists working with people in their own homes and communities, over a successive number of weeks.
What is the VALID study doing?
We have been using the Dutch intervention as a basis for developing a similar intervention for people with dementia and their carers / supporters who live in the UK. We are undertaking research to see if we can achieve the positive results through this intervention that were obtained in the Netherlands. People who receive the intervention (COTiD-UK) will be compared to those who receive usual care and services, to see if there are positive results for people with dementia and their carers/supporters from the intervention, or not.
Recruitment will be from individuals with a diagnosis of dementia, living in the community and who have a family carer who provides 4 hours’ support a week. Unfortunately recruitment is unable to be from individuals who are currently in hospital, have a diagnosis of depression and are participating in another intervention research study.
April 2015: Dementia and Physical Activity (DAPA) Research Study
For this study we are recruiting participants who have mild to moderate dementia – are you interested in taking part?
This research study is for people with mild to moderate dementia and is running in the Gloucestershire area. It aims to understand the effects of a specially-designed exercise programme and compare it to routine care for dementia.
If you decide to take part, you will be visited at your home by a research nurse who will ask you some questions about your memory, understanding and your daily life, at three different times over a period of 12 months. Your carer, if you have one, can also choose to answer some questions. Two thirds of the people taking part in the trial will be asked to attend specially-designed exercise classes, which will take place twice a week each for one hour with a trained DAPA Physiotherapist. Travel expenses will be paid to attend the sessions for 16 weeks.
Our first group in Gloucester successfully opened at the end of May, and we are currently recruiting to a new group due to open in Cheltenham at the end of June, so we are recruiting people over the next few weeks.
Please click here to read some more information about the study. If you are interested in finding out more, please contact the ²gether Research Team asking to speak to Genevieve Riley on 01452 894048 or email email@example.com.
September 2014: MADE – Minocycline in Alzheimer’s Disease Efficacy Trial
This is a randomised, double-blind placebo controlled clinical trial to test efficacy and tolerability of Minocylcine in disease modification of Alzheimer’s disease.
What is this study about?
This clinical trial is running within ²gether NHS Foundation Trust in Gloucestershire.
MADE is a randomised controlled trial looking to determine whether Minocylcine (a commonly prescribed antibiotic) is superior to placebo in affecting the disease course of early Alzheimer’s Disease over a 2 year period, measured by reduced rate of decline in cognition and function.
Please click here for more in depth information.
Who can take part?
- Those with a diagnosis of probable or possible mild-moderate Alzheimer’s disease.
- Standardised Mini Mental State Exam (sMMSE) score of more than 23
- Able to give informed consent
What is involved?
For those who consent to take part, participants will be randomised to 24 months of daily treatment with 400mg Minocycline, 200mg Minocycline or placebo. They will undergo assessments with a Clinical Studies Officer to measure their cognition and functioning. Participants will be closely followed-up during this time.
How do I get involved?
If you are interested in taking part or would like some more information, please contact the Principle Investigator Dr Tarun Kuruvilla on 01242 634460 or 2gnft.Research@nhs.net.
Our Performance in Initiating and Delivering Clinical Research
You can find out more about our performance here.